Modified Nucleotides in tRNALys and tRNAVal are Important for Translocation
作者： Steven S. Phelps , Andrzej Malkiewicz , Paul F. Agris , Simpson Joseph
DOI: 10.1016/J.JMB.2004.02.070
关键词:
摘要: Ribosomes translate genetic information encoded by messenger RNAs (mRNAs) into proteins. Accurate decoding the ribosome depends on proper interaction between mRNA codon and anticodon of transfer RNA (tRNA). tRNAs from all kingdoms life are enzymatically modified at distinct sites, particularly in near anticodon. Yet, role these naturally occurring tRNA modifications translation is not fully understood. Here we show that nucleosides first, or wobble, position 3'-adjacent to important for translocation ribosome's aminoacyl site (A site) peptidyl (P site). Thus, contribute functional groups conformational dynamics critical accurate P during protein synthesis.
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