Effects of epidural morphine and transdermal fentanyl analgesia on physiology and behaviour after abdominal surgery in pigs

摘要: Summary The objective of this work was to evaluate the physiological and behavioural effects opioid analgesic treatment in pigs subjected abdominal surgery. Ten Swedish Landrace � Yorkshire (2074kg b.w.) were submitted for intestinal cannulation. allocated into two groups during one preoperative, surgical postoperative days. All anaesthetized with medetomidine, tiletamine zolazepam. One group treated epidural morphine (0.1mg/kg) preoperatively, transdermal fentanyl patches (50mg/kg/h) applied behind ear immediately after other received saline (equivalent volume) placebo patches. regularly weighed clinically examined repeated blood samples analysed serum concentrations cortisol, b-endorphin fentanyl. Pre- behaviours evaluated by a swine specialist blinded treatment, three times day, also videotape recorded total 84h per pig. No differences behaviour noted observer. During first 12h, did not differ activity compared preoperative recordings, while untreated found be less active. started show interest eating anaesthesia recovery, whereas not. 12‐60h period, had lower levels levels, which similar those group. Treated gained 0.570.2kg subsequent days, lost weight throughout experiment. Cortisol concentration differed surgery: Group P 3257120nmol/L M 159749nmol/L. between groups. highest (0.3770.3ng/mL) measured 24h postoperatively. Preoperative combination resulted earlier return normal an immediate gain