Impaired slow wave sleep downscaling in encephalopathy with status epilepticus during sleep (ESES).

摘要: Abstract Objective “Encephalopathy related to electrical status epilepticus during slow wave sleep” (ESES) is characterised by the electroencephalographic pattern of continuous spike waves sleep (CSWS) and variable neuropsychological impairments. The synaptic homeostasis hypothesis predicts that strength synapses decreased sleep. slope NREM best reflects this “downscaling”. Methods In a retrospective case control study, we analysed time course EEG nine patients with ESES. showed (>85%) associated regression or stagnation cognitive functions. data patient group were compared healthy age gender matched controls. Results subjects found expected decrease from first last hour (17.2% decrease, p Conclusions This finding may reflect disruption downscaling process sleep, which contribute developmental in these children. Significance Thus, our findings understanding pathomechanisms leading observed children ESES support view goal treatment should not only be reduce seizures, but also resolve activity.