Prejunctional prostaglandin receptors in the human iris-ciliary body

摘要: Prostaglandins (PGs) of the E series have been shown to modulate sympathetic neurotransmitter release in a variety peripheral tissues and organs, including eye. In this study, we evaluated inhibitory effects naturally-occurring synthetic PGs on field stimulation-evoked H-norepinephrine (H-NE) from isolated, superfused segments human iris-ciliary body. Field-stimulated H-NE secretion was calcium-dependent, blocked by selective inhibitors voltage-sensitive calcium sodium channels, originated desipramine-sensitive transmitter pool. Evoked inhibited concentration-dependent manner PGE2 (EC50 =45 nM) several closely related compounds with following rank order potency: sulprostone > 16,16-dimethyl-PGE2 11-deoxy-PGE1. By contrast, PGF2α relatively inactive 10 μ, UM) system. None above significantly modified spontaneous efflux. -mediated inhibition not antago...