Beyond Tethering the Viral Particles: Immunomodulatory Functions of Tetherin (BST-2).
作者： Ritudhwaj Tiwari , Juan C. de la Torre , Dorian B. McGavern , Debasis Nayak
关键词:
摘要: Host response to viral infection is a highly regulated process involving engagement of various host factors, cytokines, chemokines, and stimulatory signals that pave the way for an antiviral immune response. The manifested in terms sequestration, phagocytosis, inhibition genome replication, and, finally, if required, lymphocyte-mediated clearance virally infected cells. During this process, cross-talk between factors can shape disease outcomes immunopathology. Bone marrow stromal antigen 2 (BST-2), also know as tetherin, induced by type I interferon produced infections, well certain cancers. BST-2 has been shown be restriction factor virus multiplication through its ability physically tether budding virions restrict spread. However, other roles This review focuses on diverse functions downstream signaling pathways regulating responses.
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