Genetic determinants of hypertension: an update.

摘要: Hypertension represents a global public health burden. In addition to the rarer Mendelian forms of hypertension, classic genetic studies have documented significant heritable component most common form, essential hypertension (EH). Extensive efforts are under way elucidate basis this disease. Recently, new form has been identified, pharmacogenetic association in hypertensive patients identified novel gene-by-drug interactions, and first genome-wide EH published. New findings consomic congenic rat models also offer clues architecture complex phenotype. review, authors summarize evaluate recent related gene identification.