Caenorhabditis elegans MPP+ model of Parkinson's disease for high-throughput drug screenings.

作者: Evelyn Braungart , Manfred Gerlach , Peter Riederer , Ralf Baumeister , Marius C. Hoener

DOI: 10.1159/000080983

关键词:

摘要: The neurotoxin MPTP and its active metabolite MPP+ cause Parkinson’s disease (PD)-like symptoms in vertebrates by selectively destroying dopaminergic neurons the substantia nigra. MPTP/M

参考文章(34)
C D Marsden, P Jenner, The actions of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in animals as a model of Parkinson's disease. Journal of Neural Transmission-supplement. ,vol. 20, pp. 11- 39 ,(1986)
AM Marini, JP Schwartz, IJ Kopin, The neurotoxicity of 1-methyl-4-phenylpyridinium in cultured cerebellar granule cells The Journal of Neuroscience. ,vol. 9, pp. 3665- 3672 ,(1989) , 10.1523/JNEUROSCI.09-10-03665.1989
Sascha Röhrig, Inge Röckelein, Roland Donhauser, Ralf Baumeister, Protein interaction surface of the POU transcription factor UNC-86 selectively used in touch neurons. The EMBO Journal. ,vol. 19, pp. 3694- 3703 ,(2000) , 10.1093/EMBOJ/19.14.3694
Doris J. Doudet, Grace L.Y. Chan, James E. Holden, Edith G. Mcgeer, Thomas A. Aigner, Richard J. Wyatt, Thomas J. Ruth, 6-[18F]Fluoro-L-DOPA PET studies of the turnover of dopamine in MPTP-induced parkinsonism in monkeys. Synapse. ,vol. 29, pp. 225- 232 ,(1998) , 10.1002/(SICI)1098-2396(199807)29:3<225::AID-SYN4>3.0.CO;2-8
J. Sulston, M. Dew, S. Brenner, Dopaminergic neurons in the nematode Caenorhabditis elegans The Journal of Comparative Neurology. ,vol. 163, pp. 215- 226 ,(1975) , 10.1002/CNE.901630207
Ze’ev Hochberg, Mechanisms of Steroid Impairment of Growth Hormone Research in Paediatrics. ,vol. 58, pp. 33- 38 ,(2002) , 10.1159/000064764
M. Gerlach, P. Riederer, Animal models of Parkinson's disease: an empirical comparison with the phenomenology of the disease in man. Journal of Neural Transmission. ,vol. 103, pp. 987- 1041 ,(1996) , 10.1007/BF01291788
R. Nass, D. H. Hall, D. M. Miller, R. D. Blakely, Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 3264- 3269 ,(2002) , 10.1073/PNAS.042497999