DNA Methylation-Dependent Dysregulation of GABAergic Interneuron Functionality in Neuropsychiatric Diseases.

摘要: Neuropsychiatric diseases, such as mood disorders, schizophrenia, and autism, represent multifactorial differing in causes, disease onset, severity, symptoms. A common feature of numerous neuropsychiatric conditions are defects the cortical inhibitory GABAergic system. The balance excitation inhibition is fundamental for proper efficient information processing cerebral cortex. Thus, altered suggested to account pathological symptoms like cognitive impairments dysfunctional multisensory integration. While it became apparent that most these diseases have a clear genetic component, environmental influences emerged an impact manifestation, severity. Epigenetic mechanisms transcriptional control, DNA methylation, known be responsive external stimuli, suspected implicated functional interneurons, hence, pathophysiology diseases. Here, we provide overview about multifaceted implications methylation methyltransferases interneuron development function health disease. Apart from regulation gamma-aminobutyric acid-related genes relevant development, discuss role methylation-dependent synaptic transmission by modulation endocytosis-related potential pathophysiological underlying conditions. Deciphering hierarchy changes epigenetic signatures crucial develop effective strategies treatment prevention.