The impact of hepatic portoenterostomy on liver transplantation for the treatment of biliary atresia: early failure adversely affects outcome.

摘要: Alexopoulos SP, Merrill M, Kin C, Matsuoka L, Dorey F, Concepcion W, Esquivel Bonham A. The impact of hepatic portoenterostomy on liver transplantation for the treatment biliary atresia: Early failure adversely affects outcome. Abstract:  most common indication pediatric LTx is atresia with failed HPE, yet effect previous HPE outcome after has not been well characterized. We retrospectively reviewed a single-center experience 134 consecutive transplants from 1 May 1995 to 28 April 2008. Of patients, 22 underwent without prior (NPE), while 112 patients first. were grouped into EF, defined as need within first year life, and LF, beyond life. NPE EF groups differed significantly LF group in age, weight, PELD, ICU status (p < 0.05) having highest PELD status. Patients who salvage following had higher incidence post-operative bacteremia septicemia (p < 0.05), subsequently lower survival rates. One-year patient graft follows: 100%, 81%, 96% (p < 0.05); 96%, 79%, (p < 0.05). Further investigation optimal should focus identifying at high risk may benefit proceeding directly given increased post-LTx bacteremia, sepsis, death HPE.