Hyperthermia: malformations to chaperones.

摘要: Hyperthermia has been known to induce malformations in numerous animal models as well being associated with human abnormalities. This was apparent particularly when the hyperthermia exposure during early stages of neural development. Although it recognized relatively that these exposures induced cell death, specific molecular mechanism how a brief heat translated cellular functions remains largely unknown. While our understanding events govern cells react heat, or stresses general, increased, there is much undiscovered. In this review, and clinical observations are outlined some scientific explorations were undertaken characterize, define, better understand morphological, biochemical, effects on developing embryo. Birth Defects Res (Part B) 89:279–288, 2010. © 2010 Wiley-Liss, Inc.