Physiological implications of DHEAS-induced non-classical steroid hormone signaling
作者： Dimitrios Papadopoulos , Mazen Shihan , Georgios Scheiner-Bobis
DOI: 10.1016/J.JSBMB.2017.10.002
关键词:
摘要: In the spermatogenic cell line GC-2, dehydroepiandrosterone sulfate (DHEAS), activates Src/Ras/c-Raf/Erk1/2/CREB(ATF-1) signaling cascade. Since DHEAS is present in gonads, and since spermatogenesis maturation of spermatogonia to haploid spermatozoa requires activation Erk1/2, triggering these events by might have physiological relevance. Sertoli TM4, DHEAS-induces CREB, ATF-1, stimulates expression claudin-3 claudin-5 augments transepithelial resistance, indicating formation tight junctions between adjacent cells. Thus, influencing dynamics at blood-testis barrier, which protects germ cells from immune system, play a crucial role regulation maintenance male fertility. bEnd.3 brain-derived endothelial cells, zonula occludens-1 promotes junction neighboring blood-brain barrier brain harmful factors If supports integrity also vivo, current findings lead new strategies for prevention or treatment neurological disorders associated with defects.
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