Thiamin Deficiency and Korsakoff's Syndrome: Failure to Find Memory Impairments Following Nonalcoholic Wernicke's Encephalopathy

摘要: Prolonged alcohol consumption is associated with a variety of neuropsychiatric conditions, including the dense amnesic disorder known as Korsakoff's syndrome. syndrome frequently diagnosed in alcoholics after an episode acute thiamin deficiency. The accepted view within medical literature that etiology this lies deficiency or Wernicke's encephalopathy. However, examination published reports pure unaccompanied by chronic and excessive shows that, group patients, rate progression to low. This result suggests memory impairments alcohol-related brain damage cannot be attributed alone. cognitive such still poorly understood but several lines evidence suggest multiple causal factors interact produce deficits performance. Animal models manipulate only single putative etiological factor are unlikely elucidate influences lead A study natural history needed will allow assessment individual risk their interactions.