Radiation Therapy and Vascular Malformations

摘要: The effects of ionising radiation on normal blood vessels have been observed during high dose radiotherapy administration in humans and animals. Lindsay et al. (1962) demonstrated that following the to localised segments dog abdominal aorta, arteriosclerosis occurred was indistinguishable from occurring with advancing age, progression induced lesions also progressed time. Rubin Casaret (1968) described aorta humans: wall thickened, some areas up 4 mm. intima thickened wrinkled. In regions, fibrin covered intimai surface, other regions there were mural thrombi. However, majority thickening due an increase thickness adventitia. main clinical manifestation damage large human is spontaneous rupture, 1–7 years after doses 4000–7000 cGy (Fajardo, 1982; Fajardo & Lee, 1975; Trott, 1991), although thrombosis problem may arise (Drescher al., 1984). draw attention fine vasa vasorum (supplying vessel walls oxygen nutrition) as a probable primary target. revealed subintimal infiltration by foamy macrophages or vacuolation frequent formation thrombi, which later became organised fibrosis.