Histone H3 lysine 23 acetylation is associated with oncogene TRIM24 expression and a poor prognosis in breast cancer.
作者： Li Ma , Lili Yuan , Jing An , Michelle C. Barton , Qingyuan Zhang
DOI: 10.1007/S13277-016-5344-Z
关键词:
摘要: Acetylated H3 lysine 23 (H3K23ac) is a specific histone post-translational modification recognized by oncoprotein TRIM24. However, it not clear whether H3K23ac levels are correlated with TRIM24 expression and what role may have in cancer. In this study, we collected breast carcinoma samples from 121 patients conducted immunohistochemistry to determine the of Our results demonstrated that positively levels, high both predict shorter overall survival cancer patients. We also showed higher HER2-positive patients, their were HER2 Moreover, associated estrogen receptor (ER) progesterone (PR) statuses our cohort The Cancer Genome Atlas (TCGA) carcinoma. summary, revealed an important provided further evidence small-molecule inhibitors benefit ER- PR-negative or
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