Scheduled running wheel activity indexes the specificity of pharmocological anorexia

摘要: Nondeprived male Sprague—Dawley rats that were given scheduled access to running wheels for 60 min daily ran immediately and energetically. Intraperitoneal injections of 400 μg/kg pancreatic glucagon 0.15 cholecystokinin octapeptide had no effect on running, but significantly inhibited feeding when the offered condensed milk instead wheels. This is consistent with hypothesized function these peptides as postprandial satiety signals. In contrast, 0.5 mg/kg amphetamine 75 μ M/kg LiC1, which produced similar degrees anorexia, by about 50%. Amphetamine, neither peptide, also water drinking disrupted behavioral sequence satiety. The distance run during tests was inversely related body weight, patterns drugs' effects not altered baseline differences. Scheduled wheel a robust consummatory behavior appears provide relatively valid, simple, sensitive test specificity pharmacological anorexia.