Pancreatic glucagon, food deprivation and feeding in intact and vagotomized rabbits

摘要: Thirty New-Zealand female rabbits were implanted with hepatic-portal cannulas and six simultaneously underwent bilateral subdiaphragmatic vagotomy. When recovered, all animals received pancreatic glucagon infused at 1.0 cc/min for a total dosage of 12 microgram in 3.0 cc isotonic saline. On alternate days, saline alone was as control. Twelve intact vagotomized infusions terminating food deprivations 4, 8, 24 hr while the remaining only when free feeding. The feeding behavior measured 0.5, 1 2 postinfusion. Glucagon significantly suppressed relative to 0- 4-hr-food-deprived rabbits. Longer followed by did not produce suppression, completely ineffective suppressing animals. Although infusion 4-hr food-deprived produced 38% suppression intake during first postadministration, glycogen analysis revealed no significant reduction under behavioral testing paradigm. These results indicate that can suppress without depletion liver glycogen. It is suggested satiety signal but probably through initiating glycogenolysis.