Leukotriene B4 and C4 generation by small intestinal mucosa in children with coeliac disease.

摘要: The capacity of the small intestinal mucosa to generate leukotriene B4 (LTB4) and C4 (LTC4) in children with coeliac disease (CD) was investigated by measuring production LTB4 LTC4 biopsy specimens after stimulation 10 microM calcium ionophore A23187. In addition, we examined relationship between symptoms diarrhoea. significantly higher biopsies from patients active CD than controls (p < 0.05 p 0.01, respectively). There no significant difference inactive controls. both controls, observed without These findings suggest that enhanced generation may contribute pathophysiology but would not be related development