Effects of highly purified eicosapentaenoic acid on erythrocyte fatty acid composition and leukocyte and colonic mucosa leukotriene B4 production in children with ulcerative colitis.

摘要: Background: n-3 Polyunsaturated fatty acids (PUFAs) have been suggested as a treatment for ulcerative colitis (UC). However, the efficacy of PUFAs against UC has not examined in children. Therefore, authors investigated effects eicosapentaenoic acid (EPA) on composition and leukotriene (LT) production children with UC. Methods: For 2 months administered highly purified EPA ethyl ester (EPA-E) (1.8 g/d) to remission. Colonic mucosal histology, erythrocyte membrane phospholipids, LTB 4 by leukocytes colonic mucosa were measured before after initiation EPA-E treatment. Results: No patients relapsed during study period, no significant differences detected laboratory findings obtained ingestion. There histologic scores The levels membranes significantly higher than treatment, but other showed changes. rectal was lower Conclusion: increased erythrocytes decreased produced mucosa. To assess concomitant clinical changes, we should examine long-term ingestion maintenance remission