A pilot randomized controlled trial to improve geriatric frailty

摘要: Few randomized controlled trials (RCTs) report interventions targeting improvement of frailty status as an outcome. This RCT enrolled 117 older adults (65-79 years age) in Toufen, Taiwan who scored 3-6 on The Chinese Canadian Study Health and Aging Clinical Frailty Scale Telephone Version then score ≥1 the Cardiovascular Phenotypic Classification (CHS_PCF). With a two by factorial design, subjects were randomly assigned to (Exercise nutrition, EN, n = 55 or problem solving therapy, PST, n = 57) controls (non-EN, n = 62 non-PST, n = 60). Educational booklets provided all. EN group received nutrition consultation thrice-weekly exercise-training program while PST 6 sessions 3 month. Subjects followed at 3, 6, 12 months. Primary outcome was CHS_PCF least one category (from pre-frail robust, from frail robust) baseline assessments. One hundred completed final Intention-to-treat analysis with generalized estimating equation model applied adjustment for time treatment-by-time interactions. Mean age 71.4 ± 3.7 years, 59% females. Baseline characteristic generally comparable between groups. had higher rate primary than non-EN (45% vs 27%, adjusted p = 0.008) 3 months, but not They also more increase serum 25(OH) vitamin D level (4.9 ± 7.7 1.2 ± 5.4, p = 0.006) lower percentage osteopenia (74% 89% p = 0.042) better (2.7 ± 6.1 0.2 ± 6.7, p = 0.035, 6-month) less deterioration (−3.5 ± 9.7 −7.1 ± 8.7, p = 0.036, 12-month) dominant leg extension power non-PST subjects. Some secondary outcomes improved control groups (non-EN non-PST). No adverse effects reported. three-month intervention resulted short-term (3-month) long-term effect bone mineral density (12-month) among Taiwanese community-dwelling elders. pronounce. ClinicalTrials.gov: EC0970301