Causes and outcome of seizures in liver transplant recipients

摘要: Previous studies found that seizures in orthotopic liver transplantation (OLT) herald a catastrophic neurologic event, but the were done of patients who later died and came to autopsy.We studied 630 OLT patients. Laboratory values, electroencephalography, neuroimaging, levels cyclosporine or FK506 reviewed. Neurotoxicity from immunosuppression was considered trigger for when toxic blood level increases >or=to100% documented, white matter lesions confusional state tremors present. Generalized tonic-clonic occurred 28 (4%). In 7 part an agonal event (central nervous system infection [n = 3], anoxic encephalopathy 1], cerebral edema with fulminant hepatic failure intracranial hemorrhage sepsis 1]). 17 (n 11) 6) could be implicated. Remaining causes acute uremia 1), meningioma unknown 2). All initially treated anticonvulsants. Median follow-up 2 years did not reveal seizure recurrence after discontinuation We conclude majority new-onset are indicative poor prognosis. Immunosuppression neurotoxicity is most frequent cause. Anticonvulsant therapy necessary favorable long-term outcome. NEUROLOGY 1996;47: 1523-1525