Comparative study of the biological properties of Trypanosoma cruzi I genotypes in a murine experimental model.

摘要: Chagas disease is an endemic zoonosis in Latin America and caused by the parasite Trypanosoma cruzi. This kinetoplastid displays remarkable genetic variability, allowing its classification into six Discrete Typing Units (DTUs) from TcI to TcVI. T. cruzi I presents broadest geographical distribution continent has been associated severe forms of cardiomyopathies. Recently, a particular genotype human infections reported named as TcIDOM (previously TcIa-b). shows be clonal adapted domestic cycle but so far no studies have determined biological properties (TcIDOM) sylvatic strains TcIc-e). Hence, aim this study was untangle features these genotypes murine models. We infected ICR-CD1 mice with five (two domestic, two one natural mixture) course infection during 91 days (acute chronic phase disease) terms parasitemia, tissue tropism, immune response (IgG titers) invasion means histopathology studies. Statistically significant differences were observed parasitemia curves prepatent period between strains. There IgG antibodies across Regarding histopathology, our results indicate that present higher parasitemias low levels histopathological damage. In contrast, showed lower high These highlight sympatric behavioral strains; clinical epidemiological implications are herein discussed.