Expression and phosphorylation of insulin receptor substrate 1 during rat liver regeneration

摘要: Insulin has been shown to be important for normal liver regeneration occur. The mechanisms whereby insulin may exert its effects on hepatocyte growth, however, are still unknown. rat and human receptor substrate 1 (IRS-1) is a specific target molecule the beta subunit kinase will bind signal transducing molecules containing Src homology 2 domains through multiple tyrosyl phosphorylation (TP) sites. This investigation examined how IRS-1 involved in action during growth induced by two-thirds partial hepatectomy. TP of was strikingly enhanced prior major wave DNA synthesis at 24 h; protein mRNA expression increased parallel lesser extent after subunit, which enhances activity toward IRS-1, association with IRS-1. Finally, phosphatidylinositol 3-kinase, one domains, associated following vivo. These observations suggest that play an role transmitting intracellular regulators growth.