The pathogenesis of accelerated fibrinolysis in liver cirrhosis: a critical role for tissue plasminogen activator inhibitor
作者： SL Hersch , T Kunelis , RB Jr Francis
DOI: 10.1182/BLOOD.V69.5.1315.1315
关键词:
摘要: The pathogenesis of accelerated fibrinolysis in liver cirrhosis was investigated by comparing the results specific assays for tissue plasminogen activator (tpa) antigen, tpa activity, inhibitor, and alpha-2 plasmin inhibitor (a2PI) 12 patients with markedly (dilute whole blood clot lysis time (DWBCLT) less than two hours), nine moderately (DWBCLT to four normal greater hours). Mean antigen increased all three groups, but no correlation observed between overall fibrinolytic activity as measured DWBCLT level antigen. In contrast, there a significant an equally decreased inhibition. a2PI significantly lower groups 1 2 group 3. thus appears depend critically on capacity plasma inhibitors inhibit circulating Reduced also play role.
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