Optimal control theory applied to the anti-viral treatment of AIDS

摘要: This work deals with a particular application of the optimal control theory to model related HIV infection dynamics. The mathematical adopted in this was proposed by Nowak et al. (1996), and describes dynamics viral concentration terms interaction CD4 cells cytoroxic T lymphocytes, which are responsible for immune defence organism. variable is drug dose which, turn, affects rate virus. cost function be minimized weighted sum final load accumulated side effects. Simulation results show that scheme can achieve improved quality treatment reduction quantity administered drugs, but has inconvenience necessity frequent periodic laboratory analysis provide feedback information adjust doses.