Taking advantage of tailored electrostatics and complementary hydrogen bonding in the design of nanostructures for biomedical applications
作者： Matthew T. Hunley , Afia S. Karikari , Matthew G. McKee , Brian D. Mather , John M. Layman
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摘要: Four-armed, star-shaped poly(D,L-lactide) (PDLLA) was synthesized and terminally-functionalized with either adenine or thymine complementary hydrogen bonding groups (PDLLA-A PDLLA-T, respectively). The strong led to increased viscosity below the dissociation temperature of bonds. Rheology confirmed that these bonds were thermally reversible, a sharp reduction in near 100 °C. PDLLA, PDLLA-A, PDLLA-T melt electro-spun no significant change fiber diameter (all between 3.6 4.0μm). However, blend PDLLA-A formed fibers an average 9.8 ± 2.0 μm, resulting from bond associations. Also, phospholipid 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (POPE) at 200°C uniform 6.5 ±2.0 μm.
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