Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers.
作者： Laura D. Wood , Eric S. Calhoun , Natalie Silliman , Janine Ptak , Steve Szabo
DOI: 10.1002/HUMU.9452
关键词:
摘要: Tyrosine kinases are major regulators of signal transduction cascades involved in cellular proliferation and have important roles tumorigenesis. We recently analyzed the tyrosine kinase gene family for alterations human colorectal cancers identified somatic mutations seven members this family. In study we used high-throughput sequencing approaches to further evaluate subset genes genetic other tumors. GUCY2F, EPHA3, NTRK3 breast, lung, pancreatic cancers. Our results implicate these pathogenesis tumor types suggest that they may be useful targets diagnostic therapeutic intervention selected patients.
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D Martin-Zanca, R Oskam, G Mitra, T Copeland, M Barbacid, Molecular and biochemical characterization of the human trk proto-oncogene. Molecular and Cellular Biology. ,vol. 9, pp. 24- 33 ,(1989) , 10.1128/MCB.9.1.24
Helen Davies, Chris Hunter, Raffaella Smith, Philip Stephens, Chris Greenman, Graham Bignell, Jon Teague, Adam Butler, Sarah Edkins, Claire Stevens, Adrian Parker, Sarah O'Meara, Tim Avis, Syd Barthorpe, Lisa Brackenbury, Gemma Buck, Jody Clements, Jennifer Cole, Ed Dicks, Ken Edwards, Simon Forbes, Matthew Gorton, Kristian Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jonathon Hinton, David Jones, Vivienne Kosmidou, Ross Laman, Richard Lugg, Andrew Menzies, Janet Perry, Robert Petty, Keiran Raine, Rebecca Shepherd, Alexandra Small, Helen Solomon, Yvonne Stephens, Calli Tofts, Jennifer Varian, Anthony Webb, Sofie West, Sara Widaa, Andrew Yates, Francis Brasseur, Colin S Cooper, Adrienne M Flanagan, Anthony Green, Maggie Knowles, Suet Y Leung, Leendert HJ Looijenga, Bruce Malkowicz, Marco A Pierotti, Bin T Teh, Siu T Yuen, Sunil R Lakhani, Douglas F Easton, Barbara L Weber, Peter Goldstraw, Andrew G Nicholson, Richard Wooster, Michael R Stratton, P Andrew Futreal, None, Somatic Mutations of the Protein Kinase Gene Family in Human Lung Cancer Cancer Research. ,vol. 65, pp. 7591- 7595 ,(2005) , 10.1158/0008-5472.CAN-05-1855
G. M. Pitari, M. D. Di Guglielmo, J. Park, S. Schulz, S. A. Waldman, Guanylyl cyclase C agonists regulate progression through the cell cycle of human colon carcinoma cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 7846- 7851 ,(2001) , 10.1073/PNAS.141124698
T.-L. Wang, C. Rago, N. Silliman, J. Ptak, S. Markowitz, J. K. V. Willson, G. Parmigiani, K. W. Kinzler, B. Vogelstein, V. E. Velculescu, Prevalence of somatic alterations in the colorectal cancer cell genome Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 3076- 3080 ,(2002) , 10.1073/PNAS.261714699
Stevan R. Knezevich, Deborah E. McFadden, Wen Tao, Jerian F. Lim, Poul H.B. Sorensen, A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma Nature Genetics. ,vol. 18, pp. 184- 187 ,(1998) , 10.1038/NG0298-184
Dana M Brantley, Nikki Cheng, Erin J Thompson, Qing Lin, Rolf A Brekken, Philip E Thorpe, Rebecca S Muraoka, Douglas Pat Cerretti, Ambra Pozzi, Dowdy Jackson, Charles Lin, Jin Chen, Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo. Oncogene. ,vol. 21, pp. 7011- 7026 ,(2002) , 10.1038/SJ.ONC.1205679
Nikki Cheng, Dana Brantley, Wei Bin Fang, Hua Liu, William Fanslow, Douglas Pat Cerretti, Katrin N. Bussell, Alastair D. Reith, Dowdy Jackson, Jin Chen, Inhibition of VEGF-dependent multistage carcinogenesis by soluble EphA receptors. Neoplasia. ,vol. 5, pp. 445- 456 ,(2003) , 10.1016/S1476-5586(03)80047-7
G. M. Pitari, L. V. Zingman, D. M. Hodgson, A. E. Alekseev, S. Kazerounian, M. Bienengraeber, G. Hajnoczky, A. Terzic, S. A. Waldman, Bacterial enterotoxins are associated with resistance to colon cancer Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 2695- 2699 ,(2003) , 10.1073/PNAS.0434905100
Gerard Manning, David B Whyte, Ricardo Martinez, Tony Hunter, Sucha Sudarsanam, The Protein Kinase Complement of the Human Genome Science. ,vol. 298, pp. 1912- 1934 ,(2002) , 10.1126/SCIENCE.1075762
Kris A. Steinbrecher, Steve A. Wowk, Jeffrey A. Rudolph, David P. Witte, Mitchell B. Cohen, Targeted Inactivation of the Mouse Guanylin Gene Results in Altered Dynamics of Colonic Epithelial Proliferation American Journal of Pathology. ,vol. 161, pp. 2169- 2178 ,(2002) , 10.1016/S0002-9440(10)64494-X