Evidence for a selective migration of fetus-specific CD4+CD25bright regulatory T cells from the peripheral blood to the decidua in human pregnancy.
作者： Tamara Tilburgs , Dave L. Roelen , Barbara J. van der Mast , Godelieve M. de Groot-Swings , Carin Kleijburg
DOI: 10.4049/JIMMUNOL.180.8.5737
关键词:
摘要: During pregnancy, the maternal immune system has to tolerate persistence of fetal alloantigens. Many mechanisms contribute prevention a destructive response mediated by alloreactive lymphocytes directed against allogeneic fetus. Murine studies suggest that CD4+CD25+ T cells provide specific tolerance alloantigens during pregnancy. Previous our group demonstrate significantly higher percentage activated and CD4+CD25bright are present in decidual tissue comparison with peripheral blood human In this study, we examined phenotypic functional properties derived from tissue. Depletion demonstrates regulation third party umbilical cord comparable nonpregnant controls, whereas suppressive capacity her own child is absent. Furthermore, shows reduced CD4+CD25brightFOXP3+ CD4+CD25brightHLA-DR+ compared controls. contrast, lymphocyte isolates contain high percentages regulatory phenotype able down-regulate fetus-specific fetus-nonspecific responses. These data preferential recruitment fetal-maternal interface, where they may local
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