Randomized controlled trial comparing trimethoprim/sulfamethoxazole and trimethoprim for infection prophylaxis in hospitalized granulocytopenic patients

摘要: The clinical and microbiologic efficacy of trimethoprim alone trimethoprim/sulfamethoxazole for infection prevention was evaluated in 75 patients during 92 episodes granulocytopenia. Ultimately, 60 were evaluable 77 granulocytopenia, 36 the group 41 group. incidence higher (50 percent) than (39 percent), but this did not reach statistical significance. Trimethoprim appear to be as protective when granulocyte count less 100/mm3. In receiving trimethoprim/sulfamethoxazole, aerobic gram-negative bacilli cleared from fecal surveillance cultures more often new acquired those (p 0.05). More myelosuppression observed among 0.001). These observations suggest that may optimal preventing colonization granulocytopenic combination with other agents necessary increase spectrum activity. Trimethoprim/sulfamethoxazole itself predispose toward an increased risk by prolonging myelosuppression.