Association between biological properties of human immunodeficiency virus variants and risk for AIDS and AIDS mortality.
作者： M TERSMETTE
DOI: 10.1016/S0140-6736(89)92628-7
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摘要: Abstract 49 individuals seropositive for human immunodeficiency virus (HIV) antibody were studied longitudinally the relation between in-vitro properties of their sequential HIV isolates and clinical course before after development AIDS. They classified into three groups according to syncytium-inducing capacity, replication rate, host range isolates. The most rapid progression AIDS (median 15 months) lowest survival rate following diagnosis 12·5 observed in with high-replicating, isolates, followed by non-syncytium-inducing In contrast, low-replicating, remained symptom-free during study period follow-up until > 42 months), few from this group whom developed still alive at end >34 months). addition, patients differed respect symptoms. Zidovudine treatment seemed delay onset all risk groups, although stabilisation CD4 + cell numbers was only variants.
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