Genome-wide Association Analysis of Blood-Pressure Traits in African-Ancestry Individuals Reveals Common Associated Genes in African and Non-African Populations

摘要: High blood pressure (BP) is more prevalent and contributes to severe manifestations of cardiovascular disease (CVD) in African Americans than any other United States ethnic group. Several small African-ancestry (AA) BP genome-wide association studies (GWASs) have been published, but their findings failed replicate date. We report on a large AA GWAS meta-analysis that includes 29,378 individuals from 19 discovery cohorts subsequent replication additional samples (n = 10,386), European ancestry (EA) 69,395), East Asian 19,601). Five loci (EVX1-HOXA, ULK4, RSPO3, PLEKHG1, SOX6) reached significance (p < 1.0 × 10−8) for either systolic or diastolic transethnic after correction multiple testing. Three these PLEKHG1) lack previous associations with BP. also identified one independent signal known locus (SOX6) provide evidence fine mapping four validated loci. demonstrate EA loci, considered jointly, show significant effects samples. Consequently, suggest might universal across studied populations, demonstrating multiethnic are an essential component identifying, mapping, understanding trait variability.