IFNG genotype and sex interact to influence the risk of childhood asthma
作者： Dagan A. Loisel , Zheng Tan , Christopher J. Tisler , Michael D. Evans , Ronald E. Gangnon
DOI: 10.1016/J.JACI.2011.06.016
关键词:
摘要: Background Asthma is a complex disease characterized by sex-specific differences in incidence, prevalence, and severity, but little known about the molecular basis of these sex-based differences. Objective To investigate genetic architecture sex asthma risk, we evaluated (1) associations between polymorphisms IFNG gene childhood-onset combined samples (2) interactions on risk. Methods Main sex-interaction effects diversity risk IFN-γ levels were examined birth cohort children at high for allergic diseases. Replication association was assessed an independent sample cases. Results Significant genotype-sex observed 2 single nucleotide polymorphisms, rs2069727 rs2430561, which strong linkage disequilibrium with each other. In contrast, none 10 showed significant main asthma. The interaction nonadditivity; that is, heterozygous boys had highest asthma, girls lowest effect robust to other factors limited who experienced wheezing illnesses viral infections during first 3 years life. Genotype-sex also response LPS year Finally, replicated population childhood Conclusions These results provide insight into highlight potential importance among sex, genotype, environmental pathogenesis.
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