Characterization of tumor mutation burden (TMB) in gastrointestinal (GI) cancers.

摘要: 530Background: GI cancers are generally insensitive to immune checkpoint inhibitors (ICIs). Response ICIs has been shown correlate with TMB. Herein, we attempt quantify TMB in and its correlation PD-1/PDL-1 expression. Methods: Tumor from various sites: right-sided left-sided colon (RT LT), rectal cancer (RC), small bowel adenocarcinoma (SBA), gastric (GA), anal (SCCA), hepatocellular carcinoma (HCC), esophageal squamous cell (EA E-SCC), biliary (BC), pancreatic (PA), neuroendocrine tumors (PNET), were analyzed by NextGen sequencing. was calculated using only somatic nonsynonymous missense mutations sequenced a 592-gene panel. MSI assessed fragment analysis. Correlation of PD-1/PD-L1 expression student’s t test. Results: In total, 1375 examined. Among the different types, RT LT had highest (mean:...