Tumour necrosis factor alpha in severe congestive cardiac failure.

摘要: OBJECTIVE--To examine the concentration of circulating tumour necrosis factor alpha (TNF alpha) in patients with severe congestive heart failure (New York Heart Association class IV) during one year and to correlate changes this cytokine plasma noradrenaline, renin activity, weight. DESIGN--A prospective study role TNF chronic failure. Blood samples were collected at intervals three months. SETTING--Medical research centre a teaching hospital. PATIENTS--16 stable INTERVENTIONS--Vasodilator treatment captopril or flosequinan. MAIN OUTCOME MEASURES--Changes correlation weight optimal medical for year. RESULTS--The mean was greater than upper 95% confidence interval healthy controls throughout but there considerable between within patient variation. No seen CONCLUSIONS--The stimulus resulting enhanced concentrations remains unclear any particular time not prognostic.