Comorbid Chronic Diseases and Acute Organ Injuries Are Strongly Correlated with Disease Severity and Mortality among COVID-19 Patients: A Systemic Review and Meta-Analysis

摘要: The recent outbreak of COVID-19 has been rapidly spreading on a global scale. To date, there is no specific vaccine against the causative virus, SARS-CoV-2, nor an effective medicine for treating COVID-19, thus raising concerns with respect to effect risk factors such as clinical course and pathophysiological parameters disease severity outcome in patients COVID-19. By extracting analyzing all available published data, we identified several major characteristics associated increased mortality among Specifically, preexisting chronic conditions hypertension, cardiovascular disease, kidney diabetes are strongly developing severe COVID-19; surprisingly, however, found correlation between liver severity. In addition, that both acute cardiac injury highly correlated COVID-19-related mortality. Given high comorbidity rate tissue damage, organ function should be monitored closely diagnosed this approach included when establishing new guidelines managing these high-risk patients. Moreover, additional data needed order determine whether supportive therapy can help mitigate development severe, potentially fatal complications, further studies identify pathophysiology mechanism underlying novel coronavirus-associated infectious disease. Taken together, findings provide insights regarding strategies improving management