Hepatoportal sclerosis (obliterative portal venopathy) and nodular regenerative hyperplasia in a patient with myasthenia gravis: A case report and review of the published work

摘要: Nodular regenerative hyperplasia (NRH) and hepatoportal sclerosis, also known as obliterative portal venopathy (OPV), are two causes of non-cirrhotic hypertension (NCPH). NCPH is an increasingly recognized entity that can be seen in association with collagen vascular diseases the use medications such azathioprine didanosine, but oftentimes etiology remains unidentified. We herein report a case occurring due to OPV NRH 64-year-old woman myasthenia gravis (MG), status post-thymectomy. Portal was diagnosed incidentally on computed tomography absence predisposing factors. Extensive work-up determine any underlying liver disease unrevealing. were identified biopsy. Subsequently, patient had variceal bleeding necessitated transjugular intrahepatic portosystemic shunt placement. A few similar cases setting MG have been previously reported, suggesting immunological mechanisms involved pathogenesis may contributed development NCPH.