Participation of p53 cellular tumour antigen in transformation of normal embryonic cells.

摘要: The cellular tumour antigen p53 is found at elevated levels in a wide variety of transformed cells (for reviews see refs 1, 2). Very little yet known about the precise relationship to malignant transformation. Although increase could be secondary by-product state, it equally possible that actively involved altering growth properties, especially as has been implicated regulation normal cell proliferation. We sought test whether behave manner similar genes biological system, and we demonstrate here can cooperate with activated Ha-ras oncogene transform embryonic cells. resultant foci contain markedly altered morphology which produce high p53. Cell lines established from such elicit tumours syngeneic animals.