Introduction to Ion Channels

摘要: Ion channels are integral membrane proteins that contain pathways through which ions can flow. By shifting between closed and open conformational states (‘gating’ process), they control passive ion flow the plasma membrane. Channels be gated by potential, or specific ligands, other agents, such as mechanical stimuli. The efficacy of gating process kinetics subsequent inactivation desensitization regulated intracellular mechanisms. Many types exist, with different degrees selectivity. controlling fluxes, typically regulate potential excitability, shape action trigger muscle contraction exocytosis (through Ca2+ influx), cell volume many cellular processes. In first part chapter, we give a brief introduction to main physiological aspects channels, may not familiar molecular biologists. Subsequently, reference for later chapters, summarize structural functional features channel-proteins presently known related integrin receptors.