Therapeutics And Methods For Treating Neoplastic Diseases Comprising Determining The Level Of Caveolin-1 And/Or Caveolin-2 In A Stromal Cell Sample
作者： Federica Sotgia , Michael P. Lisanti , Richard G. Pestell
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摘要: The invention provides diagnostic and therapeutic methods for neoplastic disease patients with neoplasms of, example, the breast, skin, kidney, lung, pancreas, rectum colon, prostate, bladder, epithelial, non-epithelial; lymphomas, sarcomas, melanomas, like, comprising determining level of caveolin-1 and/or caveolin-2 in stromal cells adjacent to a neoplasm.
lens.org参考文章(10)
Claude Bron, Florent C Bender, Andrew Quest, Marc A Reymond, The caveolin-1 gene and polypeptide encoded thereby and methods of use thereof ,(2001)
Isabelle Mercier, Hallgeir Rui, Richard G. Pestell, Michael P. Lisanti, Terence M. Williams, Federica Sotgia, Hyangkyu Lee, Ghada Hassan, Dolores Di Vizio, Gloria Bonuccelli, Franco Capozza, Stromal and epithelial caveolin-1 both confer a protective effect against mammary hyperplasia and tumorigenesis: Caveolin-1 antagonizes cyclin D1 function in mammary epithelial cells. American Journal of Pathology. ,vol. 169, pp. 1784- 1801 ,(2006) , 10.2353/AJPATH.2006.060590
Isabelle Mercier, Mathew C. Casimiro, Chenguang Wang, Anne L. Rosenberg, Judy Quong, Alimatou Minkeu, Kathleen G. Allen, Christiane Danilo, Federica Sotgia, Gloria Bonuccelli, Jean-François Jasmin, Huan Xu, Emily Bosco, Bruce Aronow, Agnieszka K. Witkiewicz, Richard G. Pestell, Erik S. Knudsen, Michael P. Lisanti, Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumor suppressor functional inactivation: Implications for the response to hormonal therapy Cancer Biology & Therapy. ,vol. 7, pp. 1212- 1225 ,(2008) , 10.4161/CBT.7.8.6220
Dolores Di Vizio, Matteo Morello, Federica Sotgia, Richard G. Pestell, Michael R. Freeman, Michael P. Lisanti, An absence of stromal caveolin-1 is associated with advanced prostate cancer, metastatic disease and epithelial Akt activation. Cell Cycle. ,vol. 8, pp. 2420- 2424 ,(2009) , 10.4161/CC.8.15.9116
Erica K. Sloan, Daniel R. Ciocca, Normand Pouliot, Anthony Natoli, Christina Restall, Michael A. Henderson, Mariel A. Fanelli, Fernando D. Cuello-Carrión, Francisco E. Gago, Robin L. Anderson, Stromal Cell Expression of Caveolin-1 Predicts Outcome in Breast Cancer The American Journal of Pathology. ,vol. 174, pp. 2035- 2043 ,(2009) , 10.2353/AJPATH.2009.080924
Agnieszka K. Witkiewicz, Mathew C. Casimiro, Abhijit Dasgupta, Isabelle Mercier, Chenguang Wang, Gloria Bonuccelli, Jean-François Jasmin, Philippe G. Frank, Richard G. Pestell, Celina G. Kleer, Federica Sotgia, Michael P. Lisanti, Towards a new "stromal-based" classification system for human breast cancer prognosis and therapy. Cell Cycle. ,vol. 8, pp. 1654- 1658 ,(2009) , 10.4161/CC.8.11.8544
Agnieszka K. Witkiewicz, Abhijit Dasgupta, Katherine Nguyen, Chengbao Liu, Albert J. Kovatich, Gordon F. Schwartz, Richard G. Pestell, Federica Sotgia, Hallgeir Rui, Michael P. Lisanti, Stromal caveolin-1 levels predict early DCIS progression to invasive breast cancer Cancer Biology & Therapy. ,vol. 8, pp. 1071- 1079 ,(2009) , 10.4161/CBT.8.11.8874
Stephanos Pavlides, Diana Whitaker-Menezes, Remedios Castello-Cros, Neal Flomenberg, Agnieszka K. Witkiewicz, Philippe G. Frank, Mathew C. Casimiro, Chenguang Wang, Paolo Fortina, Sankar Addya, Richard G. Pestell, Ubaldo E. Martinez-Outschoorn, Federica Sotgia, Michael P. Lisanti, The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma Cell Cycle. ,vol. 8, pp. 3984- 4001 ,(2009) , 10.4161/CC.8.23.10238
Agnieszka K. Witkiewicz, Abhijit Dasgupta, Federica Sotgia, Isabelle Mercier, Richard G. Pestell, Michael Sabel, Celina G. Kleer, Jonathan R. Brody, Michael P. Lisanti, An Absence of Stromal Caveolin-1 Expression Predicts Early Tumor Recurrence and Poor Clinical Outcome in Human Breast Cancers The American Journal of Pathology. ,vol. 174, pp. 2023- 2034 ,(2009) , 10.2353/AJPATH.2009.080873
Gyorgy Petrovics, Albert Dobi, Kee-Hong Kim, Shiv Srivastava, Methods, kits, and systems for diagnosing and prognosing prostate cancer using secreted biomarkers ,(2007)