Epigenomic Biomarkers for the Advance of Personalized Medicine

摘要: Epigenetic factors (DNA methylation, histone modifications, or ncRNAs) are involved in gene expression regulation. Thus, determining abnormal epigenetic changes is a suitable approach to extract meaningful information about human diseases. An altered pattern of modifications has been firstly defined as hallmark for cancer, although it also key element many common diseases, such cardiovascular, metabolic, and neurological pathologies. During the last decade, advent genome-scale analysis techniques applied epigenetics provided massive amount data, enabling an important advance molecular mechanisms underlying disease initiation, progression, expansion. Disease-specific epigenomic signatures, mainly based on DNA methylation analysis, have studied several clinical purposes including prognostics diagnostics, well disease-specific chemotherapy response. Using noninvasive specimens, profiling holds promise being value management patients, even at early stages disease. Additionally, marks catalogued targets pharmacological drugs. The upgrade research epigenomics together with other –omics would tackle unanswered questions field, paving path achieve more precise personalized medicine.