Estrogen receptor β promotes the vasculogenic mimicry (VM) and cell invasion via altering the lncRNA-MALAT1/miR-145-5p/NEDD9 signals in lung cancer.
作者： Weiwei Yu , Jie Ding , Maio He , Yuan Chen , Ronghao Wang
DOI: 10.1038/S41388-018-0463-1
关键词:
摘要: While estrogen receptor β (ERβ) may impact the progression of non-small cell lung cancer (NSCLC), its linkage to alteration vasculogenic mimicry (VM) formation influence NSCLC invasion remains unclear. Here, we analyzed immunohistochemistry data from tissues and found that ERβ-positive female patients had worse survival outcomes than those ERβ-negative patients. In vitro studies using multiple lines also revealed ERβ could increase VM invasion. Molecular mechanism dissection suggested lncRNA-MALAT1 (MALAT1) expression via directly binding response elements (EREs) located on promoter MALAT1, which then lead (i) suppressing miR145-5p (ii) increasing NEDD9 protein as can target 3'-UTR NEDD9-mRNA. A preclinical study in vivo mouse model further confirmed data. Together, results above demonstrated promote altering ERβ/MALAT1/miR145-5p/NEDD9 signaling. Targeting this newly identified signaling pathway with small molecules help development novel therapies better suppress metastasis.
nature.com
sci-hub.se 参考文章(69)
Elena Shagisultanova, Anna V. Gaponova, Rashid Gabbasov, Emmanuelle Nicolas, Erica A. Golemis, Preclinical and clinical studies of the NEDD9 scaffold protein in cancer and other diseases. Gene. ,vol. 567, pp. 1- 11 ,(2015) , 10.1016/J.GENE.2015.04.086
Yifeng Jiang, Wei Chen, Rongrong Wu, Weimin Li, Zhixing Qiu, Zhuang Luo, Overexpression of estrogen receptor beta is a prognostic marker in non-small cell lung cancer: a meta-analysis International Journal of Clinical and Experimental Medicine. ,vol. 8, pp. 8686- 8697 ,(2015)
Lucheng Zhu, Jihong Liu, Shenglin Ma, Shirong Zhang, None, Long Noncoding RNA MALAT-1 Can Predict Metastasis and a Poor Prognosis: a Meta-Analysis. Pathology & Oncology Research. ,vol. 21, pp. 1259- 1264 ,(2015) , 10.1007/S12253-015-9960-5
Stephen Safe, Transcriptional activation of genes by 17β-estradiol through estrogen receptor-Sp1 interactions Vitamins and Hormones Series. ,vol. 62, pp. 231- 252 ,(2001) , 10.1016/S0083-6729(01)62006-5
Kazuya Morimoto, Tomoaki Tanaka, Yujiro Nitta, Keiko Ohnishi, Hidenori Kawashima, Tatsuya Nakatani, NEDD9 crucially regulates TGF-β-triggered epithelial-mesenchymal transition and cell invasion in prostate cancer cells: Involvement in cancer progressiveness The Prostate. ,vol. 74, pp. 901- 910 ,(2014) , 10.1002/PROS.22809
Shikai Liu, Lili Song, Saitian Zeng, Liang Zhang, MALAT1-miR-124-RBG2 Axis Is Involved in Growth and Invasion of HR-HPV-positive Cervical Cancer Cells Tumor Biology. ,vol. 37, pp. 633- 640 ,(2016) , 10.1007/S13277-015-3732-4
Ying Wu, Hongbing Liu, Xuefei Shi, Yanwen Yao, Wen Yang, Yong Song, The long non-coding RNA HNF1A-AS1 regulates proliferation and metastasis in lung adenocarcinoma. Oncotarget. ,vol. 6, pp. 9160- 9172 ,(2015) , 10.18632/ONCOTARGET.3247
Ruilei Liu, Jie Li, Yuanhui Lai, Yi Liao, Ruiming Liu, Wanshou Qiu, Hsa-miR-1 suppresses breast cancer development by down-regulating K-ras and long non-coding RNA MALAT1 International Journal of Biological Macromolecules. ,vol. 81, pp. 491- 497 ,(2015) , 10.1016/J.IJBIOMAC.2015.08.016
Kenneth McIntosh, John C. Selner, Lelan Langston, David W. Hudgel, Viral and Bacterial Infections in Adults with Chronic Asthma1,2 The American review of respiratory disease. ,vol. 120, pp. 393- ,(1979) , 10.1164/ARRD.1979.120.2.393
Robert A. Casero, Stephen B. Baylin, Barry D. Nelkin, Gordon D. Luk, Human lung tumor sensitivity to difluoromethylornithine as related to ornithine decarboxylase messenger RNA levels Biochemical and Biophysical Research Communications. ,vol. 134, pp. 572- 579 ,(1986) , 10.1016/S0006-291X(86)80458-2