The blood-brain barrier and methamphetamine: open sesame?

摘要: The chemical and electrical microenvironment of neurons within the central nervous system is protected segregated from circulation by vascular blood-brain barrier. This barrier operates on level endothelial cells includes regulatory crosstalk with neighboring pericytes, astrocytes, neurons. Within this neurovascular unit, form a formidable, highly regulated through presence inter-endothelial tight junctions, absence fenestrations, almost complete fluid-phase transcytosis. potent psychostimulant drug methamphetamine transiently opens either or both modulation junctions induction Direct action endothelium induces acute opening In addition, striatal effects resultant neuroinflammatory signaling can indirectly lead to chronic dysfunction Breakdown may exacerbate neuronal damage that occurs during abuse. However, process also constitutes rare example agonist-induced breakdown adjunctive use present an opportunity enhance delivery chemotherapeutic agents underlying neural tissue.