Effect of peripheral lipopolysaccharide injection on dopamine content in murine anterior olfactory nucleus.
作者： K. Mori , Y. S. Kaneko , A. Nakashima , K. Fujiwara , I. Nagatsu
DOI: 10.1007/S00702-002-0771-Y
关键词:
摘要: Norepinephrine turnover rate in the murine locus coeruleus (LC) is known to be enhanced by intraperitoneal (i.p.) injection of lipopolysaccharide (LPS). Approximately 40% LC neurons are also project olfactory bulb (OB) and anterior nucleus (AON). Therefore, we investigated whether an i.p. 500 μg LPS could modulate catecholamine biosynthesis these sites 8-week-old C3H/HeN male mice. Unexpectedly, content norepinephrine was not elevated both during 6-h-observation after injection. The contents dopamine its metabolites AON were highly increased at 4 h injection, whereas those OB 6-h-observation. Although has been considered belong dopaminergic neuron system, our report first show under a stressful condition such as endotoxemia.
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