Effect of Aspartame on Oxidative Stress and Monoamine Neurotransmitter Levels in Lipopolysaccharide-Treated Mice
作者： Omar M. E. Abdel-Salam , Neveen A. Salem , Jihan Seid Hussein
DOI: 10.1007/S12640-011-9264-9
关键词:
摘要: This study aimed at investigating the effect of the sweetener aspartame on oxidative stress and brain monoamines in normal circumstances and after intraperitoneal (ip) administration of lipopolysaccharide (LPS; 100 μg/kg) in mice. Aspartame (0.625–45 mg/kg) was given via subcutaneous route at the time of endotoxin administration. Mice were euthanized 4 h later. Reduced glutathione (GSH), lipid peroxidation (thiobarbituric acid-reactive substances; TBARS), and nitrite concentrations were measured in brain and liver. Tumor necrosis factor …
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sci-hub.se 参考文章(67)
Amany A. Sleem, Omar M. E. Abdel Salam, Nermeen M. Shaffie, Hepatoprotective effects of citric acid and aspartame on carbon tetrachloride-induced hepatic damage in rats ,(2009) , 10.17877/DE290R-15693
B. Halliwell, Free radicals, proteins and DNA: oxidative damage versus redox regulation. Biochemical Society Transactions. ,vol. 24, pp. 1023- 1027 ,(1996) , 10.1042/BST0241023
K. Mori, Y. S. Kaneko, A. Nakashima, K. Fujiwara, I. Nagatsu, A. Ota, Effect of peripheral lipopolysaccharide injection on dopamine content in murine anterior olfactory nucleus. Journal of Neural Transmission. ,vol. 110, pp. 31- 50 ,(2003) , 10.1007/S00702-002-0771-Y
Christos Pantelis, Murat Yücel, Michael Berk, Stephen J. Wood, Neurobiology of schizophrenia spectrum disorders: the role of oxidative stress. Annals Academy of Medicine Singapore. ,vol. 38, pp. 396- 401 ,(2009)
Howard L. Weiner, Sharon M. Wahl, Wenwen Jin, Wanjun Chen, Melissa Cook, Oral delivery of group A streptococcal cell walls augments circulating TGF-beta and suppresses streptococcal cell wall arthritis. Journal of Immunology. ,vol. 161, pp. 6297- 6304 ,(1998)
Hidehiko Yokogoshi, Richard J. Wurtman, Acute effects of oral or parenteral aspartame on catecholamine metabolism in various regions of rat brain. Journal of Nutrition. ,vol. 116, pp. 356- 364 ,(1986) , 10.1093/JN/116.3.356
P A Spiers, L Sabounjian, A Reiner, D K Myers, J Wurtman, D L Schomer, Aspartame : neuropsychologic and neurophysiologic evaluation of acute and chronic effects The American Journal of Clinical Nutrition. ,vol. 68, pp. 531- 537 ,(1998) , 10.1093/AJCN/68.3.531
William C. Sessa, Lief Eric Olsson, Robert M. Weiss, Marcia A. Wheeler, Bladder instillation and intraperitoneal injection of Escherichia coli lipopolysaccharide up-regulate cytokines and iNOS in rat urinary bladder. Journal of Pharmacology and Experimental Therapeutics. ,vol. 284, pp. 1203- 1208 ,(1998)
Chunyu Cao, Kiyoshi Matsumura, Kanato Yamagata, Yasuyoshi Watanabe, Induction by lipopolysaccharide of cyclooxygenase-2 mRNA in rat brain; its possible role in the febrile response Brain Research. ,vol. 697, pp. 187- 196 ,(1995) , 10.1016/0006-8993(95)00839-I
Nicolas P Turrin, Dave Gayle, Sergey E Ilyin, Mark C Flynn, Wolfgang Langhans, Gary J Schwartz, Carlos R Plata-Salamán, Pro-inflammatory and anti-inflammatory cytokine mRNA induction in the periphery and brain following intraperitoneal administration of bacterial lipopolysaccharide. Brain Research Bulletin. ,vol. 54, pp. 443- 453 ,(2001) , 10.1016/S0361-9230(01)00445-2