Aggregation of activated platelets with Walker 256 carcinoma cells.

摘要: Walker 256 carcinoma cells form irreversible aggregates with rat platelets activated by ADP or serotonin. Since serotonin induces platelet shape change but not aggregation the degree of activation indicated disc-sphere transformation is sufficient for to interact these tumor cells. This confirmed experiments spheroid washed which mixed without a stimulus being required. type could react in vivo, provided are disturbed blood flow contact subendothelium. Our observations can explain why other authors found no interaction between and non-activated vitro even though contributed formation bloodborne metastases this tumor.