HMG-CoA reductase inhibitors deplete circulating classical and non-classical monocytes following human heart transplantation

摘要: Abstract Background Monocytes mediate immune responses following solid organ transplantation via cytokine secretion and differentiation to macrophage/dendritic cell lineages. To date, the pleiotropic immunomodulatory effect of statins on human monocytes heart has yet be elucidated. This study was designed assess effects statin administration monocyte repertoire. Methods 108 patients were recruited into study. Clinical data collected from patients' notes. Peripheral blood immunophenotype determined flow cytometry (using CD11c, CD14, CD16, CD49d, CD64, CD80 CD195). Results There fewer circulating classical ( p  = 0.0001) non-classical  = 0.0013) in treated with a statin. CD64 expression down-regulated  = 0.011  = 0.049) whereas CD49d up-regulated  = 0.004  = 0.022) this group. Patients receiving Atorvastatin had  = 0.001) compared administered Pravastatin. Pravastatin  = 0.029) Atorvastatin. Discussion Statin alters repertoire transplantation, including population size, FcγRI VLA-4 adhesion molecule expression. Furthermore, different treatments are associated selective depletion macrophage or DC (re)generating monocytes.