Synthesis, characterization, DNA binding and cleavage, BSA interaction and anticancer activity of dinuclear zinc complexes
作者： Chun-Yan Gao , Xin Qiao , Zhong-Ying Ma , Zhi-Gang Wang , Jing Lu
DOI: 10.1039/C2DT31306E
关键词:
摘要: Three new zinc(II) complexes: [Zn2(L1)2Cl2](ClO4)2·C2H5OH (1) and [Zn2L2X4]·2CH3CN (X = Br for 2, Cl 3), utilizing two interrelated di-nucleating polypyridyl ligands (L1, L2), have been synthesized characterized by using various physico-chemical techniques. The interactions of three complexes with CT-DNA explored absorption, emission CD spectral methods, which reveal that bind to partial intercalation binding modes. Notably, in the presence H2O2 as a revulsant or an activator, cleavage abilities all are obviously enhanced. hydrolytic mechanism was demonstrated adding standard radical scavengers anaerobic reaction. Further, protein ability has monitored quenching tryptophan BSA model protein. mechanisms static procedures. In addition, vitro cytotoxicity on human tumor cells lines (HeLa, MCF-7 RL952) apoptosis-inducing activity 3 were assessed MTT, Clonogenic assay, Hoechst 33342 staining, Cell cycle Annexin V experiments.
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