Sex differences in morphine analgesia: an experimental study in healthy volunteers.
作者： Elise Sarton , Erik Olofsen , Raymonda Romberg , Jan den Hartigh , Benjamin Kest
DOI: 10.1097/00000542-200011000-00018
关键词:
摘要: BackgroundAnimal and human studies indicate the existence of important sex-related differences in opioid-mediated behavior. In this study authors examined influence morphine on experimentally induced pain healthy male female volunteers.MethodsYoung men women (10 each
asahq.org
sci-hub.se 参考文章(19)
Peter McCullagh, John Ashworth Nelder, Generalized Linear Models ,(1983)
Theodore J. Cicero, Edward R. Meyer, Bruce Nock, Sex-related differences in morphine's antinociceptive activity: relationship to serum and brain morphine concentrations. Journal of Pharmacology and Experimental Therapeutics. ,vol. 282, pp. 939- 944 ,(1997)
Judith S. Walker, John J. Carmody, Experimental pain in healthy human subjects: gender differences in nociception and in response to ibuprofen. Anesthesia & Analgesia. ,vol. 86, pp. 1257- 1262 ,(1998) , 10.1097/00000539-199806000-00023
K. Elaine Tighe, Andrew M. Webb, Gregory J. Hobbs, Persistently high plasma morphine-6-glucuronide levels despite decreased hourly patient-controlled analgesia morphine use after single-dose diclofenac: potential for opioid-related toxicity. Anesthesia & Analgesia. ,vol. 88, pp. 1137- 1142 ,(1999) , 10.1097/00000539-199905000-00032
G.W. Hanks, G.W. Aherne, P.J. Hoskin, P. Turner, P. Poulain, EXPLANATION FOR POTENCY OF REPEATED ORAL DOSES OF MORPHINE? The Lancet. ,vol. 330, pp. 723- 725 ,(1987) , 10.1016/S0140-6736(87)91083-X
Jorn Lotsch, Gerd Kobal, Anne Stockmann, Kay Brune, Gerd Geisslinger, , Lack of analgesic activity of morphine-6-glucuronide after short-term intravenous administration in healthy volunteers. Anesthesiology. ,vol. 87, pp. 1348- 1358 ,(1997) , 10.1097/00000542-199712000-00014
Jill S Boyer, Michael M Morgan, Rebecca M Craft, Microinjection of morphine into the rostral ventromedial medulla produces greater antinociception in male compared to female rats Brain Research. ,vol. 796, pp. 315- 318 ,(1998) , 10.1016/S0006-8993(98)00353-9
Russell K Portenoy, Howard T Thaler, Charles E Inturrisi, Hamutal Friedlander-Klar, Kathleen M Foley, The metabolite morphine-6-glucuronide contributes to the analgesia produced by morphine infusion in patients with pain and normal renal function Clinical Pharmacology and Therapeutics. ,vol. 51, pp. 422- 431 ,(1992) , 10.1038/CLPT.1992.42
Walter A. Brown, The Placebo Effect Scientific American. ,vol. 278, pp. 90- 95 ,(1998) , 10.1038/SCIENTIFICAMERICAN0198-90
Benjamin Kest, Elise Sarton, Albert Dahan, Dennis M. Fisher, Gender differences in opioid-mediated analgesia: animal and human studies. Anesthesiology. ,vol. 93, pp. 539- 547 ,(2000) , 10.1097/00000542-200008000-00034