A sensitive docetaxel assay in plasma by solid-phase extraction and high performance liquid chromatography-UV detection: validation and suitability in phase I clinical trial pharmacokinetics.
作者： Claude Joseph Ardiet , Brigitte Tranchand , Sylvie Zanetta , Aline Guillot , Elisabeth Bernard
关键词:
摘要: We have developed a specific and sensitive method aiming atdocetaxel (Taxotere®) determination in plasma of treatedpatients. This involved solid-phase extraction 1 ml plasmaonto carboxylic acid (CBA) grafted silica cartridges followed byreversed-phase liquid chromatography with UV detection. The bestselectivity was obtained through the use C18 Uptisphere® asstationary phase. low limit quantitation (LOQ:5 ng/ml) allowed measurements docetaxel up to 24 hours afterone-hour infusions dosages drug (60 mg/m2). Themethod applied successfully monitor levelswithin two protocols associating fixed either methotrexate or gemcitabine escalating doses Taxotere®.
springer.com
sci-hub.se 参考文章(20)
V. Diéras, P. Furnoleau, S. Kalla, J.L. Misset, N. Azli, P. Pouillart, Docetaxel in combination with doxorubicin or vinorelbine European Journal of Cancer. ,vol. 33, ,(1997) , 10.1016/S0959-8049(97)90005-8
Georg Hempel, Doris Lehmkuhl, Sebastian Krümpelmann, Gottfried Blaschke, Joachim Boos, Determination of paclitaxel in biological fluids by micellar electrokinetic chromatography Journal of Chromatography A. ,vol. 745, pp. 173- 179 ,(1996) , 10.1016/0021-9673(96)00351-2
Ann Warner, Michael Privitera, David Bates, Standards of laboratory practice: antiepileptic drug monitoring Clinical Chemistry. ,vol. 44, pp. 1085- 1095 ,(1998) , 10.1093/CLINCHEM/44.5.1085
R Bruno, D Hille, A Riva, N Vivier, W W ten Bokkel Huinnink, A T van Oosterom, S B Kaye, J Verweij, F V Fossella, V Valero, J R Rigas, A D Seidman, B Chevallier, P Fumoleau, H A Burris, P M Ravdin, L B Sheiner, Population pharmacokinetics/pharmacodynamics of docetaxel in phase II studies in patients with cancer. Journal of Clinical Oncology. ,vol. 16, pp. 187- 196 ,(1998) , 10.1200/JCO.1998.16.1.187
John R. Eckardt, Antitumor activity of docetaxel American Journal of Health-system Pharmacy. ,vol. 54, ,(1997) , 10.1093/AJHP/54.SUPPL_2.S2
Vicente Valero, Combination Docetaxel/Cyclophosphamide in Patients With Advanced Solid Tumors Oncology. ,vol. 11, pp. 38- 40 ,(1997)
Matti S. Aapro, Combination Docetaxel/Vinorelbine for Metastatic Breast Cancer and Non-Small-Cell Lung Cancer Oncology. ,vol. 11, pp. 46- 49 ,(1997)
Howard A. Burris, Docetaxel in combination with fluorouracil for advanced solid tumors. Oncology. ,vol. 11, pp. 50- 52 ,(1997)
Valero, Paclitaxel and epirubicin as first-line therapy for patients with metastatic breast cancer. Oncology. ,vol. 11, pp. 34- 37 ,(1997)
C. M. Kearns, Hak Choy, W. Akerley, M. J. Glantz, B. F. Cole, C. H. Rhodes, M. J. Egorin, Weekly paclitaxel with and without concurrent radiation therapy: toxicity, pharmacokinetics, and response. Seminars in Oncology. ,vol. 23, pp. 128- 135 ,(1996)