Ethanol induced changes in glycosylation of mucins in rat intestine
作者： R.K. Grewal , A . Mahmood
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摘要: The epithelial surface of intestinal tract is covered by a mucosal layer, which constitutes the first line defense against exposure variety exogenous or endogenous agents. This coat rich in mucins, secreted goblet cells. In present study, we investigated effect feeding 1 ml 30% ethanol daily for different durations on mucin glycosylation rat intestine. Ethanol 15 days had no effect, but secretion from cells was enhanced rats exposed to 25-56 days. Alkaline phosphatase and sucrase activities were augmented luminal mucins animals fed compared controls.Chemical analysis, revealed an increase hexose sialic acid contents reduced levels fucose treated with controls.These alterations may be pathological significance, since are involved protection adhesion microorganisms lumen.
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