Animal model and methods for its use in the selection of cytotoxic antibodies
作者： Jeffrey V. Ravetch
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摘要: The present invention relates to non-human animals and in vivo methods for testing the efficacy of antibodies directed antigens expressed by tumors such animals. In particular, an animal deficient expression one or more Fc receptors. Additionally, is also immunodeficient, thus permits growth a xenogeneic tumor implant. Such immunodeficient may express human evaluating enhanced ability existing antibody Fc-modified act as immunotherapeutic eradicate cells infectious agents.
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